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New Cardiology research.

The strongest recent Cardiology papers on PubMed, ranked by study design, topic and journal, with the same summaries subscribers get.

  1. randomized trial, 3,825 patients

    Quantitative Flow Ratio- vs Angiography-Guided Percutaneous Coronary Intervention: A Secondary Analysis of the FAVOR III China Trial

    Zhang H, Shi Y, Guan C, et al. JAMA Netw Open. Oct 2026.

    Findings
    In patients with multivessel disease, QFR-guided PCI significantly reduced 3-year MACE to 12.1% compared to 18.1% with angiography guidance (hazard ratio, 0.65; P < .001). In the non-multivessel cohort, MACE rates were 8.6% versus 11.0% (P = .09).
    Bottom line
    QFR-guided PCI reduces 3-year major adverse cardiac events in multivessel coronary disease (12.1% vs 18.1%, HR 0.65).

    PubMed, PMID 42911591

  2. systematic review, 10,115 studies

    Diagnostic accuracy of high-sensitivity point-of-care troponin assays in emergency department for patients presenting with chest pain: a systematic review

    Daalen LEV, Schueler BLF, Collinson PO, et al. Eur J Emerg Med. Oct 2026.

    Findings
    The review included 11 studies with a total of 10 115 patients. Reported sensitivities were 98.8‑100% for Atellica VTLi at troponin <4 ng/L (NPV 99.8‑100%) and 100% for Atellica VTLi at troponin <7 ng/L (NPV 100%). Pathfast showed sensitivity 96.3‑100% for troponin <3 ng/L (NPV 98.1‑100%). i‑STAT achieved sensitivity 99.8% for troponin <5 ng/L (NPV 100%).
    Bottom line
    Across 11 studies (10 115 patients), high‑sensitivity POCT troponin assays demonstrated sensitivities ranging from 96.3‑100% and NPVs up to 100% at low ng/L thresholds.

    PubMed, PMID 42894477

  3. randomized trial, 466 patients

    Impact of Extent of Coronary Artery Disease in Transcatheter Aortic Valve Replacement: A PRO-TAVI Substudy

    Broeze GM, Aarts HM, da Silva Voorham J, et al. JACC Cardiovasc Interv. Oct 2026.

    Findings
    In a trial substudy of 466 patients with coronary disease undergoing TAVR, PCI deferral with SYNTAX score >17 increased 1-year ischemic composite outcomes (30.9% vs 14.8%; adjusted HR 2.43, 95% CI 1.04-5.64, P = 0.04).
    Bottom line
    PCI deferral in TAVR patients with complex coronary disease (SYNTAX score >17) increases 1-year ischemic risk.

    PubMed, PMID 42863875

  4. systematic review, 4 studies

    Single versus double transseptal puncture for atrial fibrillation radiofrequency ablation: a systematic review and meta-analysis

    Xu J, Zhang W, Ye F, et al. Front Cardiovasc Med. Jan 2026.

    Findings
    In 4 studies: OR 1.20, 95% CI: 0.95-1.51, <i>P</i> = 0.13
    Bottom line
    MD 11.65, 95% CI: 2.62-20.69, <i>P</i> = 0.01

    PubMed, PMID 42898279

  5. randomized trial, 4,398 patients

    Occlusion-Focused Triage vs Very-High-Risk NSTEMI Criteria: A DIFOCCULT-3 Substudy

    Aslanger EK, Aggül B, Yıldırımtürk Ö, et al. JACC Cardiovasc Interv. Oct 2026.

    Findings
    In 4,398 patients without diagnostic ST-elevation, an occlusion-focused approach increased early invasive management (45.4% vs 13.6%, p<0.001) and 2-hour acute occlusion identification (35.1% vs 16.7%, p<0.001) compared to standard guidelines.
    Bottom line
    The OMI/NOMI framework improves rapid identification and immediate invasive management of acute coronary occlusions.

    PubMed, PMID 42863867

  6. meta-analysis, 4 studies

    Risk of myocardial infarction in adults with gout treated with allopurinol: A systematic review and meta-analysis

    Leon-Rodriguez JA, Agreda-Gil RL, Diaz-Rimarachin WS, et al. Diab Vasc Dis Res. Jan 2026.

    Findings
    Across four cohort studies, allopurinol use was associated with a reduced myocardial infarction risk (HR 0.84, 95% CI 0.76‑0.94).
    Bottom line
    Allopurinol therapy modestly lowers myocardial infarction risk in adults with gout.

    PubMed, PMID 42912780

  7. prospective cohort, 22 patients

    Myocardial External Efficiency and Energetic Adaptation After Heart Transplantation: An Exploratory Study

    Berg Okholm K, Kjærulff MLG, Berg Hansen K, et al. Transplantation. Oct 2026.

    Findings
    Myocardial external efficiency increased from 18 ± 5% to 21 ± 5% at 6 months after heart transplantation (P = 0.003). It remained below the 26 ± 6% observed in controls (P < 0.0001).
    Bottom line
    Myocardial external efficiency improves after transplantation to 21 ± 5% and correlates with strain (r = -0.49).

    PubMed, PMID 42925569

  8. systematic review, 23 studies

    Comparative Outcomes of Self-Expanding Versus Balloon-Expandable Valves in Severe Aortic Stenosis: A Systematic Review and Meta-Analysis

    Elazab A, Ali AHG, Elbataa A, et al. Cardiol Rev. Oct 2026.

    Findings
    In patients undergoing TAVR, SEV achieved a greater reduction in mean pressure gradient compared with BEV (MD -4.48, 95% CI -5.29 to -3.67; P < 0.0001). However, SEV had higher risks of pacemaker implantation (RR 1.40) and moderate-to-severe paravalvular leakage (RR 2.28).
    Bottom line
    While SEV provides superior hemodynamic performance, it increases the risk of pacemaker placement (RR 1.40).

    PubMed, PMID 42928070

Summaries are written by AI from PubMed abstracts, for keeping up with the literature. Check the source before it changes care. Editorial policy · Medical disclaimer

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