Specialties / Clinical Genetics
New Clinical Genetics research.
The strongest recent Clinical Genetics papers on PubMed, ranked by study design, topic and journal, with the same summaries subscribers get.
-
randomized trial, 207 patients
Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial
Andemariam B, Kuo KHM, Algahtani FH, et al. Lancet. Oct 2026.
- Findings
- In the trial, 56 (41%) of 138 mitapivat‑treated patients achieved a ≥1 g/dL hemoglobin increase versus 2 (3%) of 69 on placebo, and the annualised pain crisis rate was 2·6 versus 3·1 per year.
- Bottom line
- Mitapivat yields a 38% higher hemoglobin response rate (56/138 vs 2/69) without significantly reducing pain crises.
Summaries are written by AI from PubMed abstracts, for keeping up with the literature. Check the source before it changes care. Editorial policy · Medical disclaimer
Get Clinical Genetics research every morning.
Free. Choose your Clinical Genetics topics after you subscribe.