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New General Surgery research.

The strongest recent General Surgery papers on PubMed, ranked by study design, topic and journal, with the same summaries subscribers get.

  1. randomized trial, 84 patients

    Dual benefit of esketamine-based opioid-free anesthesia on postoperative pain and mental health outcomes in patients undergoing bariatric surgery: a randomized controlled trial

    Huang C, Guan Z, Wang S, et al. Transl Psychiatry. Jul 2026.

    Findings
    A total of 84 patients were randomized (42 per arm) and 74 (88.1%) completed 3‑month follow‑up; esketamine‑based OFA yielded significantly lower pain intensity (P < 0.01) and better mental health outcomes.
    Bottom line
    Esketamine‑based opioid‑free anesthesia improves postoperative analgesia and mental health without raising adverse events in bariatric surgery patients.

    PubMed, PMID 42893989

  2. randomized trial, 328 patients

    Multimodal prehabilitation in colorectal cancer surgery: randomized clinical trial

    Bjerregaard F, Pekkari K, Asklid D, et al. BJS Open. Sep 2026.

    Findings
    In 242 patients undergoing colorectal resection, postoperative complications occurred in 47.5% of the prehabilitation group versus 45.0% of controls, showing no significant benefit. Severe complications affected 19.0% overall, with a non‑significant trend toward fewer in the intervention arm.
    Bottom line
    Multidisciplinary prehabilitation did not reduce complication rates (47.5% vs 45.0%) after colorectal cancer surgery.

    PubMed, PMID 42925093

  3. randomized trial, 66 patients

    PlasmaLyte, Lactated Ringer's, or Normal Saline resuscitation in acute pancreatitis: a single-center, pragmatic, cluster-randomized trial

    Sin SH, Kim HK, Choi HH, et al. BMC Gastroenterol. Jul 2026.

    Findings
    Among 66 acute pancreatitis patients, SIRS prevalence fell to 4.8% with PlasmaLyte (80% reduction), 12.5% with Lactated Ringer’s (57.1% reduction) and 9.5% with Normal Saline (50% reduction).
    Bottom line
    Balanced crystalloids lowered SIRS more than saline, though differences were not statistically significant.

    PubMed, PMID 42897479

  4. randomized trial, 70 patients

    Adjuvant 904 nm Gallium Arsenide Laser Therapy Enhances Healing and Reduces Bacterial Burden in Chronic Wounds: A Randomized Controlled Trial

    Baracho VDS, Silva NCD, Godinho LF, et al. Wound Repair Regen. Jan 2026.

    Findings
    In 70 patients, the AL group had a 53% reduction in wound area, while the PL group had a 9% reduction (p < 0.001).
    Bottom line
    904 nm GaAs laser therapy accelerates chronic wound healing, reduces bacterial load, and improves tissue remodeling, supporting its use as an adjunct to standard care.

    PubMed, PMID 42921882

Summaries are written by AI from PubMed abstracts, for keeping up with the literature. Check the source before it changes care. Editorial policy · Medical disclaimer

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