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New Internal Medicine research.

The strongest recent Internal Medicine papers on PubMed, ranked by study design, topic and journal, with the same summaries subscribers get.

  1. randomized trial, 96 patients

    Effects of E-Coach-Based Chronic Disease Management on Self-Management, Quality of Life, and Mental Health in Maintenance Hemodialysis Patients

    Zhang Y, Xing J, Wang GX, et al. J Vis Exp. Oct 2026.

    Findings
    In hemodialysis patients, self-management scores improved significantly with E-Coach compared with usual care, showing a mean difference of +11.6 (95%CI: 9.7 to 13.6; p < 0.001 by Bonferroni correction). The between-group difference in change was +13.3 (95%CI: 9.9 to 16.5).
    Bottom line
    Adding an E-Coach intervention effectively boosts self-management behavior scores in maintenance hemodialysis patients.

    PubMed, PMID 42921780

  2. randomized trial

    Gut virome remodeling after fecal microbiota transplantation is associated with virus-bacteria co-variation and metabolic response in obesity and type 2 diabetes

    Jiang H, Peng Y, Lam B, et al. Gut Microbes. Dec 2026.

    Findings
    Random forest classification gave 84.8% accuracy for post‑FMT virome changes and 81.4% for bacteriome changes in distinguishing LDL responders. Donor viral contig engraftment occurred in 64.7% (11/17) of recipients with FMT alone and 58.8% (10/17) with FMT plus lifestyle intervention, compared with 5.6% (1/18) in the sham plus lifestyle group.
    Bottom line
    Virome remodeling after FMT shows comparable predictive power to bacteriome shifts and markedly higher donor viral engraftment than sham treatment.

    PubMed, PMID 42912803

  3. phase i trial, 1,195 patients

    Community-based traditional Chinese medicine health service use among older adults and provider-reported delivery barriers in Wuhan, China: an explanatory sequential mixed-methods study

    Yue Y, Fu J, Gu J, et al. BMC Health Serv Res. Sep 2026.

    Findings
    In Wuhan, 1,195 adults aged ≥ 60 years were surveyed; 729 of them (61.0%) reported receiving at least one community‑based traditional Chinese medicine health service.
    Bottom line
    More than half (61.0%) of the 1,195 seniors accessed community TCM care.

    PubMed, PMID 42902286

  4. prospective cohort, 49 patients

    Incidence and Progression of Acute Kidney Injury Following Head and Neck Surgeries for COVID-19-Associated Mucormycosis: A Prospective Observational Study

    Rapeti KM, Karim HMR, Panda CK, et al. Cureus. Sep 2026.

    Findings
    In this cohort of 49 patients, 9 (18.4%) developed postoperative AKI. AKI patients had lower eGFR (87.4 vs 102.9 mL/min/1.73 m²) and higher hypertension prevalence (77.8% vs 32.5%).
    Bottom line
    Watch renal function and hypertension in ROCM surgery patients, as 18.4% develop AKI with lower eGFR and higher hypertension rates.

    PubMed, PMID 42894582

  5. prospective cohort, 100 patients

    Cardiometabolic Risk Factors, Obesity Phenotypes, and Novel Anthropometric Indices in Patients With Acute Coronary Syndrome: A Hospital-Based Case-Control Study in Central India

    Boob S, Manohar T, Shaikh FI, et al. Cureus. Sep 2026.

    Findings
    In a case-control study, 50 ACS patients and 50 matched controls were compared. Hypertension was present in 60% of cases versus 36% of controls; diabetes in 52% versus 28%; dyslipidemia in 56% versus 32%; and smoking in 44% versus 24% (all p<0.05). Using metabolically healthy normal weight as reference, the metabolically unhealthy obese phenotype had an odds ratio of 3.33 for ACS (95% CI 1.10-10.12).
    Bottom line
    Metabolic obesity phenotypes markedly increase ACS odds, with MUO showing a 3.33‑fold higher risk.

    PubMed, PMID 42892963

  6. phase iii trial

    Outcomes by Comorbidities with Tremelimumab and Durvalumab in the Randomized, Controlled Phase 3 HIMALAYA Study in Unresectable Hepatocellular Carcinoma

    Rimassa L, Dayyani F, Kelley RK, et al. Liver Cancer. Jul 2026.

    Findings
    In the HIMALAYA trial, STRIDE produced a 48‑month OS of 28.0% for patients with cardiovascular comorbidities and 20.4% for those with metabolic comorbidities, with long‑term survival in 28.2% and 22.6% respectively.
    Bottom line
    STRIDE provides comparable 48‑month OS whether or not patients have cardiovascular (28.0%) or metabolic (20.4%) comorbidities, and long‑term survival in about a quarter of each subgroup.

    PubMed, PMID 42924082

  7. systematic review, 4 studies

    Caries experience in patients with coronary heart disease: a systematic review

    Eliasz W, Gawriołek M, Urbanowicz T, et al. Minerva Dent Oral Sci. Oct 2026.

    Findings
    Four studies (total up to ~4000 participants) reported higher mean DMFT and more untreated decay in coronary artery disease patients versus controls.
    Bottom line
    Patients with coronary disease have higher DMFT and more untreated decay, suggesting greater caries burden.

    PubMed, PMID 42922385

  8. randomized trial, 34 patients

    Efficacy of anterioposterior weight-shift training with visual biofeedback for step length asymmetry and functional mobility in chronic stroke: a randomized controlled trial

    Lee JW, Jo YJ, Baek YS, et al. J Neuroeng Rehabil. Jul 2026.

    Findings
    In a randomized trial of 34 chronic stroke patients, the AP training group showed significant improvements in the Step Length Asymmetry Index (p < 0.05) and in maximum safe walking speed (p < 0.05).
    Bottom line
    Clinicians can expect AP weight‑shift training to reduce gait asymmetry and raise safe walking speed, both reaching statistical significance (p < 0.05).

    PubMed, PMID 42897557

Summaries are written by AI from PubMed abstracts, for keeping up with the literature. Check the source before it changes care. Editorial policy · Medical disclaimer

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