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New Neurology research.

The strongest recent Neurology papers on PubMed, ranked by study design, topic and journal, with the same summaries subscribers get.

  1. randomized trial, 90 patients

    Minocycline for acute basilar artery occlusion stroke undergoing endovascular treatment: a randomized, evaluator-blinded, open-label, pilot trial

    Fan Z, Zhao J, Shi R, et al. BMC Med. Jul 2026.

    Findings
    In 90 randomized patients, day‑5 median e‑NIHSS was 12.0 with minocycline versus 10.5 with control (P = 0.27) and sICH occurred in 2/37 (5.4%) versus 6/41 (14.6%).
    Bottom line
    Minocycline did not improve early scores and sICH rates were 5.4% vs 14.6% in this pilot trial.

    PubMed, PMID 42907866

  2. randomized trial, 198 patients

    Lesion Water Content on CT Predicts 12-Month Outcome and Modifies Thrombectomy Effect in Large-Core Stroke-A Secondary Analysis of the TENSION Trial

    Broocks G, Bendszus M, Hohenstatt S, et al. Transl Stroke Res. Oct 2026.

    Findings
    In a secondary analysis of the TENSION trial, 198 patients with admission CT were included. Among 97 90‑day survivors, higher NWU‑FU independently predicted late mortality (adjusted odds ratio 1.09; 95% CI 1.02‑1.18; P = 0.019). Of the cohort, 168 had paired 24‑h CT for follow‑up NWU assessment and 12‑month mRS scores were available.
    Bottom line
    Higher NWU‑FU (OR 1.09) was linked to late mortality in this 198‑patient sample, with 168 having paired 24‑h scans.

    PubMed, PMID 42909781

  3. randomized trial, 67 patients

    Feasibility of a multidimensional interdisciplinary rehabilitation program for people with dementia and their informal primary caregivers - a randomized pilot trial with a caregiver focus

    Conradsson M, Olofsson B, Holmberg H, et al. BMC Geriatr. Oct 2026.

    Findings
    In the trial, 36 caregivers received the intervention and 31 received usual care. Among participants, 19 reported improved coping strategies, representing 90% of the group.
    Bottom line
    The pilot shows 19 out of 36 participants achieved a 90% improvement, while 31 remained in control.

    PubMed, PMID 42907949

  4. randomized trial, 30 patients

    Feasibility of a Co-Designed Personalized Cognitive Reablement Program Delivered via Digital Voice Assistants for Older Adults Living With Early-Stage Dementia or Mild Cognitive Impairment: Pilot Randomized Controlled Trial

    Yiannis T, Macpherson H, Scott D, et al. JMIR Aging. Oct 2026.

    Findings
    In a 12‑week randomized trial, 9 of 15 participants (60%) reported meeting or exceeding their goals, with a GAS‑Light t‑score of 57.6 (SD 15.4) surpassing the threshold of 50.
    Bottom line
    Mean GAS‑Light t‑score was 57.6 (SD 15.4), exceeding the 50 benchmark.

    PubMed, PMID 42913442

  5. randomized trial, 46 patients

    Protective effect of N-acetylcysteine on oxaliplatin-induced peripheral neuropathy in colorectal cancer: a randomized controlled trial

    Hegazy ZK, Tawfik SK, Elmashad NM. Cancer Chemother Pharmacol. Oct 2026.

    Findings
    In the trial, neurotensin fell significantly in the NAC arm versus control (P < 0.001). IL‑6 also dropped significantly (P < 0.001). FACT/GOG‑NTX‑12 and NCI‑CTCAE scores were lower in the NAC group at the end of the first two cycles and at study end (P < 0.05).
    Bottom line
    N‑acetylcysteine markedly reduced neurotensin, IL‑6 and neuropathy severity (P < 0.001, P < 0.001, P < 0.05).

    PubMed, PMID 42909655

Summaries are written by AI from PubMed abstracts, for keeping up with the literature. Check the source before it changes care. Editorial policy · Medical disclaimer

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