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New Pathology research.

The strongest recent Pathology papers on PubMed, ranked by study design, topic and journal, with the same summaries subscribers get.

  1. phase iii trial, 714 patients

    Relatlimab plus nivolumab versus nivolumab for advanced melanoma: 5-year survival and biomarker analyses of the phase 3 RELATIVITY-047 trial

    Long GV, Dolfi S, Hodi FS, et al. Nat Med. Oct 2026.

    Findings
    At 5-year follow-up, nivolumab plus relatlimab showed improved progression-free survival (hazard ratio = 0.77; 95% confidence interval: 0.65-0.92) and overall survival (hazard ratio = 0.78; 95% confidence interval: 0.64-0.95) compared to nivolumab alone.
    Bottom line
    Dual LAG-3 and PD-1 blockade maintains durable survival benefits over monotherapy in advanced melanoma.

    PubMed, PMID 42926136

  2. phase iii trial, 378 patients

    Evaluation of Potential Prognostic Biomarkers for Identifying Adults Hospitalised with COVID-19 at Increased Risk of Adverse Clinical Outcomes

    Hu X, Setiadi AF, Detalle L, et al. Adv Ther. Oct 2026.

    Findings
    A composite score derived from baseline IL-6 levels and neutrophil percentage identified high-risk patients (scores ≤ 72.1). This high-risk group had an estimated hazard ratio of mortality of 14.3 (95% confidence interval 4.1, 49.3; P < 0.0001).
    Bottom line
    Combining baseline IL-6 and neutrophil percentage effectively stratifies mortality risk in hospitalized COVID-19 patients.

    PubMed, PMID 42928084

  3. meta-analysis, 32,169 patients

    Microatherosclerosis is a common but often overlooked cause of ischemic stroke

    Waghmare S, Leal-Hidalgo R, Saver JL. Front Neurol. Jan 2026.

    Findings
    In a meta‑analysis of 24 series (32,169 patients), lacunar infarcts comprised 17.8% of strokes and microatherosclerosis accounted for 43% of lacunar strokes and 7.7% of all ischemic strokes.
    Bottom line
    Microatherosclerosis is a common cause, representing 43% of lacunar strokes and 7.7% of all ischemic strokes.

    PubMed, PMID 42898271

  4. systematic review, 726 studies

    From MRI-defined bone marrow lesions to pain, structural progression, and subchondral remodeling in knee osteoarthritis: an integrated multi-database bibliometric and text-mining analysis

    Zhang Y, Zhao Z. Front Med (Lausanne). Jan 2026.

    Findings
    An analysis of 726 publications mapped research on MRI-defined bone marrow lesions in knee osteoarthritis. The literature expanded across six research domains linking imaging with progression and symptoms.
    Bottom line
    Research on bone marrow lesions in knee osteoarthritis is organized across six domains linking imaging phenotypes to clinical outcomes.

    PubMed, PMID 42920564

Summaries are written by AI from PubMed abstracts, for keeping up with the literature. Check the source before it changes care. Editorial policy · Medical disclaimer

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