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New Surgical Oncology research.

The strongest recent Surgical Oncology papers on PubMed, ranked by study design, topic and journal, with the same summaries subscribers get.

  1. systematic review, 1,005 patients

    Liver transplantation as a treatment option for neuroendocrine liver metastases: a systematic review

    Jaén-Torrejimeno I, López-Guerra D, Rojas-Holguín A, et al. Cir Cir. Jan 2026.

    Findings
    In a systematic review of 1005 patients (mean age 47.9 years), disease‑free survival after liver transplantation was reported as 25.3 months, ranging from 14 to 31 months.
    Bottom line
    The data suggest that liver transplantation can provide a disease‑free interval of about 25.3 months for patients with neuroendocrine liver metastases.

    PubMed, PMID 42913616

  2. prospective cohort, 285 patients

    Neutrophil-to-Lymphocyte Ratio Is Associated with Disease Progression in a Surveillance Cohort of Patients with Branch-Duct IPMN

    Hansen FJ, Ewald P, Sorncharoen L, et al. J Clin Med. Oct 2026.

    Findings
    During follow-up, 63 patients (22.1%) developed at least one WF, and patients with an NLR above the cohort median (>2.36) had approximately twofold higher odds of subsequent disease progression (OR, 2.02; 95% CI, 1.02-3.98).
    Bottom line
    Elevated NLR is linked to higher risk of BD‑IPMN progression, with an OR of 2.02 for patients above the median NLR.

    PubMed, PMID 42882217

  3. observational study, 1,000 patients

    Risk assessment of multi-focal side-branch IPMNs: Long-term follow-up of one thousand patients

    Wehrle CJ, Khan F, Nadeem MA, et al. Pancreatology. Oct 2026.

    Findings
    Among 1,000 patients, 370 (37%) had multifocal SB‑IPMNs; high‑risk pathology occurred in 4.3% overall (3.2% multifocal vs 4.8% solitary) and CR‑progression predicted malignancy (HR 31.3, 95% CI 16.3‑62.1).
    Bottom line
    Multiplicity does not raise malignant risk, but clinicians should monitor CR‑progression, which markedly predicts high‑risk pathology.

    PubMed, PMID 42897050

  4. phase iii trial

    Outcomes by Comorbidities with Tremelimumab and Durvalumab in the Randomized, Controlled Phase 3 HIMALAYA Study in Unresectable Hepatocellular Carcinoma

    Rimassa L, Dayyani F, Kelley RK, et al. Liver Cancer. Jul 2026.

    Findings
    In the HIMALAYA trial, STRIDE produced a 48‑month OS of 28.0% for patients with cardiovascular comorbidities and 20.4% for those with metabolic comorbidities, with long‑term survival in 28.2% and 22.6% respectively.
    Bottom line
    STRIDE provides comparable 48‑month OS whether or not patients have cardiovascular (28.0%) or metabolic (20.4%) comorbidities, and long‑term survival in about a quarter of each subgroup.

    PubMed, PMID 42924082

  5. phase ii trial, 37 patients

    Systemic antitumor responses to hypofractionated radiotherapy plus Poly(I:C) in advanced hepatocellular carcinoma: A phase 2 trial

    Qiu L, Huang Q, Pan X, et al. Med. Oct 2026.

    Findings
    In 37 patients, HFRT + Poly(I:C) achieved a 54.5% objective response versus 21.2% with HFRT alone, a 45.0% abscopal response versus 10.5%, and extended progression‑free survival to 8.4 months (HR 0.542).
    Bottom line
    HFRT + Poly(I:C) markedly improves response rates and survival metrics compared with HFRT alone in advanced HCC.

    PubMed, PMID 42901168

  6. meta-analysis, 13 studies

    Sleep disorders as an emerging risk factor for liver cirrhosis and hepatocellular carcinoma: a systematic review and meta-analysis of cohort studies

    Peng TR, Wu TW, Lin HH, et al. BMC Gastroenterol. Jul 2026.

    Findings
    A systematic review of thirteen cohort studies found insomnia linked to a higher hazard ratio of 1.39 for liver outcomes, with the confidence interval spanning 1.28 to 1.49.
    Bottom line
    Insomnia appears to increase the risk of liver cirrhosis and hepatocellular carcinoma.

    PubMed, PMID 42907764

  7. observational study, 74,162 patients

    Sociocultural Determinants of Hepatocellular Carcinoma Prevention Behaviors Among Non-Hispanic Black and Hispanic Adults in the United States

    Ekenze SO, Charalampou CM, Alizai Q, et al. J Gastrointest Surg. Oct 2026.

    Findings
    In 74,162 adults, HBV vaccination was lower in those aged 45-64 (aOR 0.38) and higher in college graduates (aOR 2.01). Alcohol moderation was higher among women (aOR 2.01) and lower in Hispanic adults (aOR 0.53).
    Bottom line
    Sociocultural and demographic determinants heavily influence hepatocellular carcinoma prevention behaviors.

    PubMed, PMID 42893742

  8. retrospective cohort, 264 liver transplantations

    Prolonged Donor Warm Ischemia in Pure Laparoscopic Donor Right Hepatectomy Is Associated With Increased Recipient Biliary Stricture Risk: A Retrospective Cohort Study

    Kim G, Lee KW, Kim MK, et al. Transplantation. Oct 2026.

    Findings
    In 264 living donor liver transplantations, donor warm ischemia time of 13 minutes or longer was an independent predictor of recipient biliary strictures requiring intervention (HR 1.88, P = 0.020).
    Bottom line
    Minimizing donor warm ischemia time during laparoscopic donor right hepatectomy is crucial to prevent recipient biliary strictures.

    PubMed, PMID 42862884

Summaries are written by AI from PubMed abstracts, for keeping up with the literature. Check the source before it changes care. Editorial policy · Medical disclaimer

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